From my own experience and responding to your question asking for the "Best Medicine with less side effects?" Google Dr. Amie Hornerman's Thyroid Fixer. It's natural and has worked wonders for me on my pain. I was in chronic pain where doctors rule out Hashimotos and say I am in good health. The osteoporosis is but a symptom for me of a deeper rooted probelm that started out with a cyst on my thyroid. Doctors will not give me medication. Years ago I was on dessicated pig thyroid but Canada pulled the plug on its distribution five years ago. I believe people can now get it but it's best to see a functional medicine practitioner who knows what they are doing. DR Amie cuts through all the crap. She does podcasts on everything thyroid. Look her up.