Osteoporosis Treatment

Posted on August 29, 2018

There are now more treatments for osteoporosis than ever before. Osteoporosis treatments fall into three main categories: Medications, surgeries, and lifestyle changes.

Types of treatments for osteoporosis

Most treatments are appropriate for primary osteoporosis. Secondary osteoporosis, which is caused by another health condition or a medication, may be treated in accordance with its specific cause. Read more about types of osteoporosis.

Your doctor may prescribe calcium and vitamin D supplements along with your osteoporosis medication. Many osteoporosis drugs are not effective – and may cause problems – if there are low levels of calcium and vitamin D in your body.

Some osteoporosis treatments are approved for women only. Many osteoporosis medications are not approved for use in women who have not yet entered menopause. Your doctor can help you find the osteoporosis treatment that is best for you.

Medications for osteoporosis

Prolia (Denosumab)

A newer treatment on the market, Prolia is a biologic drug - a genetically engineered antibody, or protein used by the immune system to identify and neutralize substances. Prolia is believed to work by limiting the number of osteoclasts – the cells that break down bone – thereby limiting the breakdown and resorption of bone. Prolia is administered once every six months by injection.

Common side effects of Prolia include bone or muscle pain, urinary tract infections, and cold symptoms. Rare but serious side effects of Prolia can include upper leg fractures, severe rashes and skin infections, and osteonecrosis (bone death) of the jaw, especially after dental surgery.


Bisphosphonates are one of the most common classes of drugs prescribed for osteoporosis. Bisphosphonate drugs include Alendronate (also known as Alendronic acid and sold under the brand name Fosamax), Reclast (Zoledronic acid), Boniva (Ibandronate), Risedronate, sold under the brand names Actonel and Atelvia.

Bisphosphonates are believed to work in cases of osteoporosis by reducing the activity of osteoclasts. Some bisphosphonates are taken orally, while others are injected intravenously. Dosing schedules vary widely, with different formulations taken each week, once a month, or even once a year.

Common side effects of bisphosphonates include bone or muscle pain and, for those taken orally, gastrointestinal problems. Rare but serious side effects of bisphosphonates can include osteonecrosis (bone death) of the jaw, especially after dental surgery.

Hormonal treatments

Sold under the brand names Fortical and Miacalcin, Calcitonin is a synthetic version of a hormone secreted by the thyroid gland. Calcitonin is believed to work by reducing the activity of osteoclasts, the cells that break down bone. Calcitonin can also improve bone pain. Calcitonin can be taken via intranasal spray or by subcutaneous or intramuscular injection. Rarely, calcitonin can increase the risk for developing certain types of cancer.

Forteo (Teriparatide) is a synthetic version of parathyroid hormone (PTH). Forteo is believed to work by stimulating the activity of osteoblasts, the cells that build bone. Forteo is taken daily by injection.

Tymlos (Abaloparatide) is an anabolic hormone believed to work in cases of osteoporosis by stimulating the body to build up bones. Tymlos is taken daily by injection.

In some women, hormone replacement therapy (HRT) may provide an effective way to prevent or treat osteoporosis. HRT replaces the estrogens and progesterone that have a protective effect on bone density before a woman goes through menopause. The most common ways to receive HRT are via oral medication, topical creams, vaginal ring, or a transdermal patch applied to the skin.

Raloxifene, sold under the brand name Evista, is a selective estrogen receptor modulator (SERM). Raloxifene is believed to work by mimicking the effects of estrogen, which helps protect bone density. Raloxifene is a tablet taken daily.

Duavee is a combination drug composed of a mixture of estrogens and Bazedoxifene (another SERM), both of which are believed to work by protecting bone density. Duavee is taken orally once a day.

Surgeries to repair fractures

In cases of osteoporosis where a vertebral compression fracture is causing severe pain or deformity that has not resolved with the use of a back brace, spinal surgery may become necessary. There are two main types of surgery for vertebral compression fractures: vertebroplasty and kyphoplasty. Both techniques are guided by X-ray imaging and may involve a small incision or a needle only. In vertebroplasty, the surgeon injects a highly specialized cement mixture into the collapsed vertebra. When the cement hardens, the vertebra will be stabilized. Stabilization prevents painful friction, further collapse, and the development of deformity. Kyphoplasty is similar to vertebroplasty, but the surgeon first inserts a small balloon into the compressed vertebra and inflates it to create space. They then inject the bone cement.

In those who experience hip fractures, hip repair or replacement surgery are usually necessary. The technique and materials used to repair or replace the hip will depend on the type of fracture. Hip surgery requires a long, slow recovery. It may take a year to recover from hip surgery, and some people never regain full mobility. The risk of death increases in the year following hip surgery.

Wrist fractures may require only a cast or splint to heal, but more complex fractures may necessitate surgery to repair.

Lifestyle changes

Diet and nutrition

For people with osteoporosis, nutrition can help build stronger bones, maintain a healthy weight, and avoid developing complications such as diabetes and heart disease. People with osteoporosis need more of some nutrients than other people. Make sure to eat plenty of foods with calcium and vitamin D to fight osteoporosis. Foods rich in vitamin D include tuna, mackerel, salmon, egg yolks, and fortified products such as some milk, soy milk, orange juice, and cereal. Calcium is present in dairy, dark leafy greens such as kale, sardines, and fortified soy milk and orange juice.

Some foods and beverages can interfere with calcium absorption. Consume these products in moderation and with care. Legumes (beans, dried peas, peanuts), nuts, and some seeds contain chemicals called phytates that can lower calcium absorption. Extremely salty foods can cause the body to lose calcium. Make sure you get sufficient protein in your diet, but avoid getting too much. Some popular high-protein diets can have a negative effect on bone mass. Too much alcohol and caffeine (especially colas) can have a negative effect on bone mineral density as well.


People with osteoporosis, especially those who have experienced fractures, may avoid exercise for fear of falling or causing additional fractures. However, staying physically active can help those with osteoporosis strengthen bones, prevent falls, decrease the risk for fractures, and improve balance and flexibility.

Your doctor can help guide you toward activities that are safe and effective for your condition. For example, activities that involve jumping, bending, or twisting may be dangerous for those with a high risk for fractures. Weight-bearing exercises strengthen bones and muscles. Weight-bearing activities can range from rapid walking to stair-climbing, using an elliptical machine, dancing, or lifting weights. Even bearing your own body weight or lifting very light weights can build bones. Many weight-bearing exercises can be done in a seated position.

Improving balance and flexibility can help you avoid falls. Regular stretching is good for flexibility. Exercises that focus on balance and flexibility include tai chi and yoga.

Daily activities such as shopping, gardening, or walking a pet can also provide safe, valuable exercise.

Other changes

If you are living with osteopenia or osteoporosis, quitting smoking is one of the best things you can do to protect your bones. Smoking has been proven to decrease bone density, raise the risk for fractures, and slow bone healing.

If you are at a high risk for fractures, consider fall-proofing your home. If you are unsteady walking, consider using a cane or walker outside the house to avoid falls.


External resources

MyOsteoTeam resources



Is there a cure for osteoporosis?

There is not yet a cure for osteoporosis.

Are there natural treatments for osteoporosis?

A nutritious diet, exercise, calcium and vitamin D supplements, and quitting smoking are all natural treatments for osteoporosis that have been proven safe and effective. Some people with osteoporosis report that they feel better after trying complementary or alternative treatments such as medical marijuana, acupuncture, reflexology, herbal supplements, massage, or aromatherapy. Since some natural or complementary treatments can interfere with osteoporosis medications or cause their own side effects, it is important to talk to your doctor before trying any alternative treatments.

What are the side effects of osteoporosis treatments?

Any medication can cause side effects. Each osteoporosis treatment has specific potential side effects associated with it. This does not mean that anyone who takes that osteoporosis medication will experience all, most, or any of the side effects it can potentially cause. Some side effects are very common, while some are extremely rare. Your doctor can help you assess the risks and benefits of each osteoporosis treatment as they relate to your medical history and condition.

Which osteoporosis treatments should I avoid?

Some osteoporosis treatments carry a higher risk of causing serious side effects than others. For this reason, there are established guidelines for which osteoporosis treatments should be tried first, which are only used in people with extremely high risk for fractures, and which should be reserved for people who do not show improvement on the first-line treatments.

However, with any medication, your risk of experiencing serious side effects depends on the details of your condition and personal and familial medical history. For instance, some osteoporosis medications carry a higher risk for people with kidney or liver problems, heart disease, or family history of certain types of cancer. With any osteoporosis medication, the risk of serious side effects must be weighed against the benefit of clinically proven effectiveness in preventing fractures.

Can I get assistance paying for osteoporosis medications?

Most people with private or employer-sponsored health insurance are eligible for copay assistance programs through the manufacturers of osteoporosis treatments. Some people with low income and no health insurance may qualify for free osteoporosis medications through non-profit organizations or drug manufacturers. You can find more information on copay assistance programs here.

A MyOsteoTeam Member said:

This information I found very useful.

posted 20 days ago

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