Tymlos (abaloparatide) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat osteoporosis in postmenopausal women and to increase bone density in men with osteoporosis who are at high risk of breaking a bone.
These insights are based on 970 comments about Tymlos from MyOsteoTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Spine bone density often improves, sometimes within the first year.
Daily at-home injections become routine for many and are often manageable.
Follow-up treatment can help maintain bone density gains after Tymlos.
Heart racing, dizziness, headache, nausea, and fatigue are common early side effects.
Bone, joint, back, or leg pain can make daily activities harder.
Treatment is limited to two years over a lifetime.
Tymlos is a bone-building medicine. It works by turning on a receptor in the body called the PTH1 receptor. This increases the activity of cells that build new bone.
Doctors prescribe Tymlos:
Tymlos is injected under the skin once each day. It is given in the abdomen. Avoid injecting within 2 inches of the belly button, and use a different injection spot each day.
Take Tymlos at about the same time every day. Do not inject it into a vein or muscle. With proper training, it can be given at home.
The recommended dose of Tymlos is 80 micrograms injected under the skin once daily.
If you do not get enough calcium and vitamin D from your diet, your healthcare provider may recommend supplements.
Tymlos is not recommended for use for more than two years total during your lifetime.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
Members who use Tymlos often say the day-to-day routine gets easier with time, especially when they find a dosing schedule and injection setup that works for them. They also frequently mention keeping a close eye on side effects, staying in touch with their doctor about labs and follow-up scans, and planning ahead for cost and what comes after Tymlos.
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In clinical studies of Tymlos, the most common side effects occurred in about 2 percent to 13 percent of people.
Side effects in postmenopausal women include:
Side effects in men include:
Tymlos can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Radius Health, Inc, the manufacturer of Tymlos, offers the Tymlos Patient Savings Card. Eligible people with commercial insurance may pay as little as $0 per month in out-of-pocket costs, subject to program limits and eligibility requirements.
The program also offers a downloadable savings card to take to the pharmacy.
To learn more, visit the Tymlos Patient Savings Card website or call 866-896-5674.
Before you take Tymlos, tell your doctor if you:
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Do not take Tymlos if you have had a serious allergic reaction to abaloparatide or any of its ingredients.
If you forget or cannot take Tymlos at your usual time, take it as soon as you can on the same day.
Do not take Tymlos if you are pregnant or planning to become pregnant. If you are breastfeeding or plan to breastfeed, tell your doctor.
These answers are fact-checked by our editorial staff.
How effective is Tymlos for osteoporosis?
In an 18-month study of postmenopausal women with osteoporosis, 0.6 percent of women taking Tymlos had a new spine fracture compared with 4.2 percent of women taking a placebo.
After 18 months, women taking Tymlos had average increases in bone mineral density of 9.2 percent in the lower spine, 3.4 percent in the total hip, and 2.9 percent in the femoral neck, which is the upper part of the thigh bone near the hip.
In a 12-month study of men with osteoporosis, average bone mineral density increased by 8.5 percent in the lower spine, 2.1 percent in the total hip, and 3 percent in the femoral neck.
How long does Tymlos take to work for osteoporosis?
Studies measured changes in markers related to bone formation during treatment. In postmenopausal women, one bone-formation marker reached its highest average increase at month 1.
Bone mineral density improvements were measured after 12 months in men and 18 months in postmenopausal women. The study does not say exactly how soon an individual person will benefit from Tymlos.
What tests or monitoring are needed with Tymlos for osteoporosis?
If your healthcare provider thinks you may have kidney stones or high calcium in your urine, they may check your urine calcium level.
Tymlos can also raise calcium levels in the blood. The prescribing information does not give a routine blood calcium testing schedule for everyone, but your healthcare provider may decide what monitoring is needed based on your health.
Before each injection, check the Tymlos solution. Do not use it if it looks cloudy, colored, or has particles in it.
On MyOsteoTeam, people share their experiences with osteoporosis, get advice, and find support from others who understand.
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